Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents. In vitro tests on acetaminophentreated precisioncut liver slices surgical procedures were carried out on fed rats under pentobarbital 60mgkg anaesthesia. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Medicinal plants containing phytochemicals with antioxidant potential have strong protective effect against hepatotoxicity 4. Introduction in ancient indian literature, it is mentioned that every plant on this earth is useful for human beings, animals and other plants. Introduction aegle marmelos, commonly known as bael, is a spiny tree belonging to the family rutaceae. The methanol extract of the fruit pulp of adansonia digitata l. The bark is traditionally used in diabetes, rheumatism.
The present study was conducted to evaluate the hepatoprotective activity of a lcoholic extract of flowers dalbergia lanata against paracetamol induced liver damage in rats. Evaluation of the hepatoprotective activity of portulaca oleracea l. A number of herbal formulations from plant origin are evaluated for their possible antioxidant and hepatoprotective effects. These systems measures the ability of the test drugs to prevent or cure liver toxicity induced by. Homalium zeylanicum flacourtiaceae is commonly known as liyan or mukki. In folklore medicine, ceriops decandra is used to treat hepatitis. Preliminary phytochemical tests were done and the ld50 values for both extracts determined.
Coldenia procumbens linn, isoniazid, pyrazinamide, rifampicin, mtt assay. These extracts were studied for their hepatoprotective activity using ccl4 induced liver. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. Hepatoprotective and antioxidant effects of licorice.
It is a nontoxic hepatoprotective substance from the himalaya drug co. Iv hepatoprotective activity of date palm phoenix dactylifera pollen grains in rats by itimad abuowf ahmed abuowf b. Therefore, from the present study it can be concluded that l. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Hepatoprotective effect of red grape seed extracts against ethanolinduced cytotoxicity hazem m. Hassan department of biochemistry, faculty of agriculture, cairo university, giza, egypt abstract. Invitro hepatoprotective activity of moringa oleifera mediated synthesis of gold nanoparticles t. The leaves, roots, bark, seeds and fruits are edible and medicinal values. University of khartoum 1993 a thesis submitted in partial fulfillment of the requirements of the university of khartoum for the degree of master in. Green tulsi ocimum sanctum, belonging to family lamiaceae are used traditionally for their hepatoprotective effect. Hepatoprotective activities of triphala and its constituents. The antioxidant and hepatoprotective activity of the plant may be attributed to the polyphenolic compounds like saponins that are present in the plant.
Hepatoprotective plants contain a variety of chemical constituents like phenols, coumarins, lignans, essential oil, monoterpenes, carotinoids, glycosides, flavanoids, organic acids, lipids, alkaloids and xanthenes 3. Hepatoprotective activity of litchi chinensis leaves. There are several chemicals have been known to induce heptotoxicity by producing reactive species which cause depletion in tissue thiol, lipid peroxidation, plasma membrane damage like carbontetrachloride, paracetomol, thioacetamide, antituberculer drugs, d galactosamine, liposachharide and arsenic etc. We wanted to evaluate the hepatoprotective activity of ocimum sanctum and observe whether synergistic. This is the first report of the hepatoprotective activity of the plant. Another study revealed that aqueous extract of bhui amla at the dose of 50 or 100 mgkg body weight for duration of 7. Alteration in the levels of biochemical markers of hepatic damage like sgot, sgpt, alp. Leaf powder of tylophora indica was successively extracted with alcohol and water. To investigate the hepatoprotective activity of alcoholic allt and aqueous aqlt extracts of leaves of tylophora indica asclepiadaceae against ethanolinduced hepatotoxicity. The present study evaluates the hepatoprotective activity of h. Evaluation of hepatoprotective activity of adansonia. It is involved with almost all the biochemical pathways to growth.
They included astragalus mongholicus, salvia miltiorrhiza, radix paeoniae alba, angelica sinensis, ligusticum wallichii, ganodorma lucidum and so on 14. Hepatoprotective activity of parmelia perlata huds. Melia azedarach, hepatoprotective activity, simvastatin, ethanol and silymarin. Hepatoprotective activity of ceriops decandra griff. These were divided into 4 groups of 6 animals each. The hepatoprotective activity of red grape seed extracts gses was. Galal1 1medicinal and aromatic plants institute, national centre for research, khartoum, sudan. The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Effect of mebp on the body weight and liver weight after induction with pcm. Malvaceae was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. Prabhakaran v, srinivas ashok kumar b, sheshadri shekar d, nandeesh r, subramanyam p and ranganayakulu d. Comparative study on hepatoprotective activity of aegle. Evaluation of hepatoprotective and antioxidant activity of ichnocarpus frutescens linn.
It is an indigenous tree found in india, myanmar, pakistan and bangladesh. Hepatoprotective activity of ocimum sanctum alcoholic leaf. Introduction liver is one of the largest organs in human body and the chief site for intense metabolism and excretion. Hepatoprotective activity of methanolic extract of. However, a scientific evaluation has not been performed. Read more about chemical constituents of sandbox tree hura crepitans linn.
The liver was perfused in situ with icecold krebsringer solution before slicing. Hepatoprotective activity of alcoholic and aqueous. Increased levels of biochemical parameters like aspartate transaminase, alanine transaminase, bilirubin and alkaline phophatase in serum, along with reduced activity of catalase and super oxide dismutase in liver were. Hepatoprotective activity of leptadenia reticulata stems. Antioxidant and hepatoprotective activity of ethanol. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr. Sitha institute of pharmaceutical sciences 2, hyderabad, andhra pradesh, india. Oral administration of an aqueous extract of andrographis 10, 20 and 30 mg per mouse caused a significant elevation of catalase, sod and glutathionestransferase activities in lymphoma. Pcm administration following pretreatment with 10% dmso significantly caused augmentation in liver weight and body weight when compared to the normal control group. Wikiproject medicine may be able to help recruit an expert. In animal experiments, the hepatotoxic group showed a coarse granulation on.
It has a surprising role in the maintenance, performance and regulating homeostasis of the body. The rats were divided into four groups, each group consisting of six animals. Group one was kept on normal diet and served as control, the second. Orthosiphon stamineus exhibited significant free radical scavenging activity with dpph ic 50 21. The toxicant ccl 4 was used to induce hepatotoxicity at a dose of 1. The hepatoprotective activity can be most easily evaluated screened with the aid of several model systems of liver damage in experimental animals.
Hepatoprotective activity of methanol extract of litsea. Department of pharmacology, biochemistry and anatomy histology section, j n medical college, amu, aligarh, india, between july 2010july 2012. Zygophyllaceae herb is widely distributed in sudan and used in sudanese traditional medicine for the treatment of various disorders. Litchi chinensis hepatoprotective leaf oxidative stress. The hepatoprotective activity of the methanol extract was assessed in paracetamol induced hepatotoxic rats. Aegle marmelos, eclipta alba, hepatoprotective activity 1. Ragunathan department of biomedical engineering, sathyabama university, rajiv gandhi salai, chennai, india centre for bioscience research centre, eachanari, coimbatore, india. Invitro hepatoprotective activity of moringa oleifera. These conditions can be cured with hepatoprotective agents. Hepatoprotective activity of solanum nigrum extracts on. Thus, the present study was carried out to identify the hepatoprotective activity of plant parts leaf, bark, collar, flower and hypocotyls of c. Interestingly, pretreatment with 500 mgkg significantly reduced the increased liver and body weight seen in.
Hence, it was proposed to carry out a preliminary in vitro analysis of the hepato protective activity of the plant, which gave promising results. Hepatoprotective activity of the lichen usnea ghattensis has been established in vitro verma et al. Mohammed ishaq 3 deccan school of pharmacy 1, hyderabad, andhra pradesh, india. Hepatoprotective effect of red grape seed extracts against. Evaluation of the hepatotoxic and hepatoprotective effect. Carbon tetrachloride ccu was used as a hepatotoxin at a dose of 0. International journal of integrative sciences, innovation and technology 20. Evaluation of hepatoprotective and antioxidant activity of. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. The alcoholic extract of flowers of dalbergia spinosa 100 and 200 mgkg was administered. In vitro antioxidant studies were carried out with dpph, hrsa, no, frap and lpo assays.
Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. Hepatoprotective activity of the methanol extract of litsea glutinosa melg was investigated by inducing hepatotoxicity with ccl4 and paracetamol in rats. To evaluate the hepatoprotective activity of ethanolic and aqueous extract of stems of leptadenia reticulata retz. Three studies cited above attest to significant in vivo and in vitro antioxidant activity for the herb, 87,93,100 as do some of the hepatoprotection studies.
The study was designed to evaluate the hepatoprotective activity of p. Male albino rats weighing between 150 and 175 g were used as animal models. Hepatoprotective activity of solanum nigrum extracts on chemically induced liver damage in rats r. The methanol extract was found to be more effective than chloroform extract. This article needs attention from an expert in medicine. In china, many plants medicines possessed hepatoprotective activity. In addition, hepatospecific serum markers will be disturbed. In all test model systems, conditions for liver damage are implemented and an attempt is made to counteract. A large number of plants and formulations have been claimed to have hepatoprotective activity. Thus, the present study was designed to investigate the hepatoprotective activity of piper longum milk extract. Hepatoprotective agents dr priyank shah, jr 1, dept of pharmacology 1 2. To screen the hepatoprotective and antioxidant activity of ethanol extract of roots of valeriana wallichii dc valerianaceaevwe. Evaluation of the hepatoprotective activity of fagonia. Hepatoprotective activity modified method of chandra et al32, was adopted in this study.
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